Microlex® povidone familys designed for the formulation of medicines

. Microlex® PVD series

Povidone, Copovidone, Crospovidone

Developed and designed for a very smooth tablet surface

. Microlex® PVD (Drug Solublization)

. Microlex® PVD K30

. Microlex® PVD K90

. Properties:

It is among the most commonly used solid dispersion carrires to solubilize poorly soluble drugs.

It can stabilize  amorphous  drugs  in  polymer dispersions and maintain supersaturation of API

aqueous solutions by preventing precipitation/crystallization

. Applications:

. Low Tg for ease of processing in hot-melt extrusion

. Solubility in wider range of solvents adds processing flexibility in spray drying

. Compatible with other ingredients to allow optimization of solid dispersion formulations for stability and delivery

. Physiologically inert for good safety profile

. Inhibits crystallization

. Microlex® C.PVD (Drug Solublization, Tablet Binding, Tablet Film Coating)

. Microlex® C.PVD S600

. Properties:

. Drug Solublization, Tablet Binding, Tablet Film Coating

. Provides a matrix to solubilize poorly soluble drugs in melt-extruded or spray-dried solid dispersions

. Applied in a wide variety of dosage forms including oral solid, liquid, and topical formulations

. A linear random water-soluble copolymer of N-vinylpyrrolidone and vinyl acetate that combines a

unique set of properties for application in a wide variety of dosage forms

. A key ingredient in high-solids film coating formulations

. Applications:

. Low Tg for ease of processing in hot-melt extrusion and spray drying

. Compatible with other ingredients to allow optimization of solid dispersion formulations for stability and delivery

. Film former for topical applications

. High bonding capabilities in granulations

. Nonionic to minimize API interactions

. Increases tablet strength and reduces friability due to high compressibility and excellent adhesive properties

. Physiologically inert for good safety profile

. Solubility in aqueous and polar organic solvents adds processing flexibility

. Improved film adhesion

. Increased processing efficiencies

. Microlex® Cr.PVD (Drug Solublization, Tablet Disintegration)

. Microlex® Cr.PVD CL-110

. Microlex® Cr.PVD CL-25

. Microlex® Cr.PVD UCL-25

. Microlex® Cr.PVD UCL-110

. Properties:

A solid dispersion carrier for drug solubilization incorporated into conventional formulations to facilitate the dissolution of poorly API due to porous surface morphology, large surface area and N-methyl vinylpyrrolidone-like unit molecular structure. Combines rapid swelling wicking (due to porosity and capillary action) and particle recovery on wetting releasing energy that facilitates disin tegration High interfacial activity enhances dissolution.

. Applications:

. Enhances solubility/dissolution of poorly soluble drugs, especially at higher use levels.

. Two key particle sizes (small particle size especially suitable for orally disintegrating tablet dosage forms)

. High compressibility for use with poorly compressible drugs

. Intragranular or extragranular application

. Nonionic for superior cationic drug dissolution

. Does not gel, so will not retard release of drug

. Compliance

. European Pharmacopoeia

. USP / NF

. Japanese Pharmacopoeia

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